|
KMID : 0380620080400060702
|
|
Korean Journal of Food Science and Technology
2008 Volume.40 No. 6 p.702 ~ p.706
|
|
|
Inhibitory Effects of Punica granatum L. Extracts on Degranulation in Human Basophilic KU812F Cells
|
|
Park Kyong-Tae
Shim Sun-Yup
Chun Soon-Sil
|
|
|
Abstract
|
|
|
|
Punica granatum (PG) evidences a variety of physiological properties, including anti-diabetic, anti-cancer, anti-inflammatory, anti-microbial, and anti-oxidative activities. Using the human basophilic KU812F cells, the inhibitory effectsof the methanolic extract of PG seed, shell, and juice on calcium ionophore, A23187-induced degranulation were assessed.All of the PG extracts inhibited A23187-induced intracellular Ca2+ levels, β-hexosaminidase, and histamine release in adose-dependent manner. These results showed that all of the PG extracts are potent inhibitors of degranulation in allergicreactions, via the suppression of Ca2+ influx.
|
|
|
KEYWORD
|
|
|
Punica granatum L., calcium influx, histamine, β-hexosaminidase, KU812F
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|